With advances in determining the entire DNA sequence of the human genome, it is now critical to identify and catalog genes for specific cellular pathways, and ultimately to formulate and modulate genomic networks in complex biological systems. This course will focus on the recent development of such genomic approaches, including chemical genomics that uses small molecules to probe and control human genomic networks. These multi-disciplinary approaches with medicinal systems biology approach will provide the relevant and creative directions for efficient discovery of drugs, therapeutic disease genes and disease networks in human bio-systems. Thus, the importance of these genome studies will be highlighted to perform basic and clinical research for diagnosis, drug discovery and development.